Opioids
Opioids are natural and synthetic drugs that include both prescription medications used to treat pain (like after surgery) and drugs such as illicitly manufactured fentanyl and heroin. They activate an area in the brain and body called opioid receptors that block pain signals between the brain and the body.
Examples of opioids
• Fentanyl (Learn more)
• Morphine
• Heroin
• Codeine
• Oxycodone (Oxycontin, Percocet)
• Hydrocodone (Vicodin)
Common forms
• Pills (both prescription and counterfeit)
• Powders or patches
• Mixed into street drugs
“Youth opioid use is linked to risky behaviors like not using a condom, and that can lead to HIV, STDs, and unintended pregnancy.” – CDC
Short-term
effects and risks
Opioids, including fentanyl, affect your brain and body quickly.
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Slow, shallow breathing
Drowsiness or unconsciousness
Nausea and vomiting
Confusion or slurred speech
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Feelings of extreme happiness (euphoria), followed by heavy drowsiness
Poor judgment and increased risk-taking
Risk of overdose
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Extreme drowsiness
Difficulty walking and talking
Blue or grey lips or nails
Pinpoint (very small) pupils
Cold and clammy skin
dizziness and confusion
Choking, gurgling, or snoring sounds
Slow, weak, or no breathing
Inability to wake up, even when shaken or shouted at
If you think someone is suffering from an opioid overdose, administer Narcan and call 911 immediately.
Long-term
effects
Opioids change how your brain works, making it harder to feel good without them. Since they produce euphoria in addition to pain relief, they can be misused and lead to an opioid use disorder (OUD).
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Organ damage (e.g., liver and lungs)
A weakened immune system
Increased tolerance, leading to the need for higher doses
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Depression, anxiety, and isolation
Difficulty focusing or maintaining relationships
Harm reduction
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If something goes wrong, someone else can call for help.
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Combining opioids with alcohol or other drugs increases the risk of overdose.
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This life-saving medication can reverse an opioid overdose.
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While fentanyl test strips have the potential to reduce fatalities, they are not 100% reliable and do not guarantee the safety of a drug. The concentration of fentanyl in counterfeit pills is inconsistent, so testing a portion of a pill may not accurately detect fentanyl.
Taking steps to reduce harm from substance use or misuse can save lives
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Bonar, E. E., Coughlin, L., Roche, J. S., Philyaw-Kotov, M. L., Bixler, E. A., Sinelnikov, S., Kolosh, A., Cihak, M. J., Cunningham, R. M., & Walton, M. A. (2020). Prescription opioid misuse among adolescents and emerging adults in the United States: A scoping review. Preventive Medicine, 132(123), 105972. https://doi.org/10.1016/j.ypmed.2019.105972
CDC. (2022, July 11). Teen newsletter: Opioids. Www.cdc.gov. https://www.cdc.gov/museum/education/newsletter/2022/july/index.html
Centers for Disease Control and Prevention. (2023, April 27). Youth risk behavior surveillance system (YRBSS). Centers for Disease Control and Prevention. https://www.cdc.gov/healthyyouth/data/yrbs/index.htm
Miech, R. A., Johnston, L. D., Patrick, M. E., & O’Malley, P. M. (2024). Monitoring the future study annual report: National survey results on drug use, 1975-2024: Overview and key findings for secondary school students. https://monitoringthefuture.org/
Miech, R., Johnston, L., O’Malley, P. M., Keyes, K. M., & Heard, K. (2015). Prescription opioids in adolescence and future opioid misuse. PEDIATRICS, 136(5), e1169–e1177. https://doi.org/10.1542/peds.2015-1364
National Institute of Health. (2022). Opioids. National Institute on Drug Abuse. https://nida.nih.gov/research-topics/opioids